Cytosporone B

Name: Cytosporone B
Brand: Tocris Bioscience
SKU: 5459

Tocris Bioscience, part of Bio-Techne | Catalog # 5459

Citations (5)

COA / SDS

High affinity Nur77 agonist

Key Product Details

Description:	High affinity Nur77 agonist
Chemical Name:	Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate
Purity:	≥98% (HPLC)
Molecular Weight:	322.4

View Full Technical Details for Cytosporone B

Technical Data
Citations

Biological Activity for Cytosporone B

Cytosporone B is a naturally occurring Nur77 (NR4A1) agonist (K_d = 8.52 x 10^-7 M). Induces apoptosis in gastric cancer cells in vitro. Increases blood glucose levels in fasting C57 mice and suppresses xenograft tumor growth. Also exhibits a potent antifibrotic effect in bleomycin-induced skin fibrosis in vivo.

Technical Data for Cytosporone B

M. Wt	322.4
Formula	C₁₈H₂₆O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	321661-62-5
PubChem ID	10687292
InChi Key	UVVWQQKSNZLUQA-UHFFFAOYSA-N
Smiles	OC1=CC(CC(OCC)=O)=C(C(CCCCCCC)=O)C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cytosporone B

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.24	100
	ethanol	32.24	100

Preparing Stock Solutions for Cytosporone B

The following data is based on the product molecular weight 322.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.10 mL	15.51 mL	31.02 mL
5 mM	0.62 mL	3.10 mL	6.20 mL
10 mM	0.31 mL	1.55 mL	3.10 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for Cytosporone B

References are publications that support the biological activity of the product.

Zhan Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat.Chem.Biol. 2008 PMID: 18690216
Palumbo-Zerr Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis. Nat.Med. 2015 PMID: 25581517