Cysmethynil

Product Description

Cysmethynil is an isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor (IC₅₀ = 2.4 μM). Cysmethynil reduces growth of RAS-mutant cell lines in vitro and in vivo (EC₅₀ = 20 μM) and reduces cell viability in a variety of cell lines (IC₅₀ = 16.8-23.3 μM). Tumor growth, mTOR signaling and cell proliferation are inhibited by cysmethynil; apoptosis is induced. Cysmethynil increases p27 and p21 proteins and arrests cell-cycle at the G₁ phase.

Solubility

Preparing Stock Solutions for Cysmethynil

The following data is based on the product molecular weight 376.54

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.66 mL	13.28 mL	26.56 mL
5 mM	0.53 mL	2.66 mL	5.31 mL
10 mM	0.27 mL	1.33 mL	2.66 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Manu Inhibition of isoprenylcysteine carboxylmethyltransferase induces cell-cycle arrest and apoptosis through p21 and p21-regulated BNIP3 induction in pancreatic cancer. Mol.Cancer Ther. 2017 PMID: 28167504
• Moore RAS-targeted therapies: is the undruggable drugged? Nat.Rev.Drug Discov. 2020 PMID: 32528145