CYN 154806

Name: CYN 154806
Brand: Tocris Bioscience
SKU: 1843

Tocris Bioscience, part of Bio-Techne | Catalog # 1843

Citations (39)

COA / SDS

Selective sst2 antagonist

Key Product Details

Description:	Selective sst₂ antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1197.35

View Full Technical Details for CYN 154806

Technical Data
Citations

Biological Activity for CYN 154806

CYN 154806 is a potent and selective somatostatin sst₂ receptor antagonist. pIC₅₀ values are 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst₂, sst₁, sst₃, sst₄ and sst₅ receptors respectively.

Technical Data for CYN 154806

M. Wt	1197.35
Formula	C₅₆H₆₈N₁₂O₁₄S₂
Single Letter Sequence	FCYWKTCY (Modifications: Phe-1 = Ac-(4-nitro)Phe, Cys-2 = D-Cys, Trp-4 = D-Trp, Tyr-8 = D-Tyr & C-terminal amide, Disulfide bridge: 2-7)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	183658-72-2
PubChem ID	16133842
InChi Key	RDTVTSXTFYXNSG-HDNDNHAUSA-N
Smiles	C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](CSSC[C@H](NC1=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(N)=O)NC(=O)[C@H](CC1=CC=C(C=C1)[N+]([O-])=O)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CYN 154806

Solubility

Soluble to 1mg/ml in water

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References for CYN 154806

References are publications that support the biological activity of the product.

Feniuk Selective somatostatin sst₂ receptor blockade with the novel cyclic octapeptide, CYN-154806. Neuropharmacology 2000 PMID: 10818260
Hannon Drug design at peptide receptors. Somatostatin receptor ligands. J.Mol.Neurosci. 2002 PMID: 11931345
Bass Identification and characterization of novel somatostatin antagonists. Mol.Pharmacol. 1996 PMID: 8863814