Cyanopindolol hemifumarate

Name: Cyanopindolol hemifumarate
Brand: Tocris Bioscience
SKU: 0993

Tocris Bioscience, part of Bio-Techne | Catalog # 0993

Citations (12)

COA / SDS

5-HT1A and 5-HT1B antagonist; also β-adrenergic antagonist

Key Product Details

Description:	5-HT_1A and 5-HT_1B antagonist; also β-adrenergic antagonist
Chemical Name:	4-[3-[tert-Butylamino]-2-hydroxypropoxy]-1H-indole-2-carbonitrile hemifumarate
Purity:	≥98% (HPLC)
Molecular Weight:	345.4

View Full Technical Details for Cyanopindolol hemifumarate

Technical Data
Citations

Biological Activity for Cyanopindolol hemifumarate

Cyanopindolol hemifumarate is a 5-HT_1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist.

Compound Libraries for Cyanopindolol hemifumarate

Cyanopindolol hemifumarate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Cyanopindolol hemifumarate

M. Wt	345.4
Formula	C₁₆H₂₁N₃O₂.½C₄H₄O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	69906-86-1
PubChem ID	45073413
InChi Key	ZSBITJKBOWVCCI-WXXKFALUSA-N
Smiles	[H]OC(=O)\C=C\C(=O)O[H].CC(C)(C)NCC(O)COC1=C2C=C(NC2=CC=C1)C#N.CC(C)(C)NCC(O)COC1=C2C=C(NC2=CC=C1)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cyanopindolol hemifumarate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.54	100

Preparing Stock Solutions for Cyanopindolol hemifumarate

The following data is based on the product molecular weight 345.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.90 mL	14.48 mL	28.95 mL
5 mM	0.58 mL	2.90 mL	5.79 mL
10 mM	0.29 mL	1.45 mL	2.90 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for Cyanopindolol hemifumarate

References are publications that support the biological activity of the product.

Blue Interaction of dihydroalprenolol and cyanopindolol with atypical β-adrenoceptors in guinea-pig ileum. Br.J.Pharmacol.
Giles Characterization of a 5-HT_1B receptor on CHO cells: functional responses in the absence of radioligand binding. Br.J.Pharmacol. 1996 PMID: 8882605
Hoey Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol. Br.J.Pharmacol. 1996 PMID: 8646418
Engel Identity of presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1_B binding sites. Naunyn Schmiedebergs Arch.Pharmacol. 1986 PMID: 2936965