CX08005

Product Description

CX08005 is a competitive PTP1B inhibitor (IC₅₀ = 0.781 μM). Binds catalytic P-loop of enzyme. Improves insulin sensitivity in obese mice in the glucose tolerance test and the homeostasis model assessment of insulin resistance index (HOMA-IR) . Enhances insulin-induced glucose uptake in adipocytes and myotubes in vitro. Exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP.

Solubility

Preparing Stock Solutions for CX08005

The following data is based on the product molecular weight 453.61

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.20 mL	11.02 mL	22.05 mL
5 mM	0.44 mL	2.20 mL	4.41 mL
10 mM	0.22 mL	1.10 mL	2.20 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Zhang A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for Ins resistance. Br.J.Pharmacol. 2016 PMID: 26990621