CX08005

Name: CX08005
Brand: Tocris Bioscience
SKU: 6144

Tocris Bioscience, part of Bio-Techne | Catalog # 6144

COA / SDS

Competitive PTP1B inhibitor

Key Product Details

Description:	Competitive PTP1B inhibitor
Chemical Name:	2-[[[2-(Tetradecyl)phenyl]amino]carbonyl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	453.61

View Full Technical Details for CX08005

Technical Data
Citations

Biological Activity for CX08005

CX08005 is a competitive PTP1B inhibitor (IC₅₀ = 0.781 μM). Binds catalytic P-loop of enzyme. Improves insulin sensitivity in obese mice in the glucose tolerance test and the homeostasis model assessment of insulin resistance index (HOMA-IR). Enhances insulin-induced glucose uptake in adipocytes and myotubes in vitro. Exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP.

Technical Data for CX08005

M. Wt	453.61
Formula	C₂₈H₃₉N0₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1256341-22-6
PubChem ID	51001376
InChi Key	WOEDXTWDPRNPMZ-UHFFFAOYSA-N
Smiles	CCCCCCCCCCCCCCOC1=C(C=CC=C1)NC(C2=C(C(O)=O)C=CC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CX08005

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.36	100
	ethanol	45.36	100

Preparing Stock Solutions for CX08005

The following data is based on the product molecular weight 453.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.20 mL	11.02 mL	22.05 mL
5 mM	0.44 mL	2.20 mL	4.41 mL
10 mM	0.22 mL	1.10 mL	2.20 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for CX08005

References are publications that support the biological activity of the product.

Zhang A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for Ins resistance. Br.J.Pharmacol. 2016 PMID: 26990621