CX 614
Tocris Bioscience, part of Bio-Techne | Catalog # 5149
Positive allosteric modulator of AMPA receptors
Key Product Details
Description
Positive allosteric modulator of AMPA receptors
Product Description
CX 614 is an AMPAkine; positive allosteric modulator of AMPA. Prototypical benzamide which occupies subsite A only. Modulates channel deactivation and desensitization.Product Specifications
Molecular Weight
247.25
Formula
C13H13NO4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2,3,6a,7,8,9-Hexahydro-11H-1,4-dioxino[2,3-g]pyrrolo[2,1-b][1,3]benzoxazin-11-one
CAS Number
191744-13-5
PubChem ID
6451148
InChI Key
RQEPVMAYUINZRE-UHFFFAOYSA-N
SMILES
O=C2N4C(CCC4)OC1=CC3=C(OCCO3)C=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.73 | 100 | |
| Ethanol | 12.36 | 50 |
Preparing Stock Solutions
for CX 614
The following data is based on the product molecular weight 247.25
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.04 mL | 20.22 mL | 40.44 mL |
| 5 mM | 0.81 mL | 4.04 mL | 8.09 mL |
| 10 mM | 0.40 mL | 2.02 mL | 4.04 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.81 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Timm Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol. 2011 PMID: 21543522
- Hennegriff Stable expression of recombinant AMPA receptor subunits: binding affinities and effects of allosteric modulators. J.Neurochem. 1997 PMID: 9166736
- Harms Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy. Neuropharmacology 2013 PMID: 22735771
Product Specific Notices for CX 614
For research use only
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