CU-T12-9

Name: CU-T12-9
Brand: Tocris Bioscience
SKU: 5414
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5414

(1)

Citations (5)

COA / SDS

Potent TLR1/2 agonist

Key Product Details

Description:	Potent TLR1/2 agonist
Chemical Name:	N-Methyl-4-nitro-2-(4-(4-trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline
Purity:	≥98% (HPLC)
Molecular Weight:	362.31

View Full Technical Details for CU-T12-9

Technical Data
Citations / Reviews (1)

Biological Activity for CU-T12-9

CU-T12-9 is a potent TLR1/2 agonist (EC₅₀ = 52.9 nM). Activates the NF-κB pathway and upregulates proinflammatory cytokines in vitro. Also enhances TLR1 and TLR2 dimerization.

Licensing Information

Sold under license from the University of Colorado

Compound Libraries for CU-T12-9

CU-T12-9 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for CU-T12-9

M. Wt	362.31
Formula	C₁₇H₁₃F₃N₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1821387-73-8
PubChem ID	91826088
InChi Key	LITXVDAFEYLWQE-UHFFFAOYSA-N
Smiles	CNC1=CC=C([N+]([O-])=O)C=C1N2C=C(C3=CC=C(C(F)(F)F)C=C3)N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CU-T12-9

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.23	100
	ethanol	7.25	20

Preparing Stock Solutions for CU-T12-9

The following data is based on the product molecular weight 362.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.80 mL	27.60 mL
5 mM	0.55 mL	2.76 mL	5.52 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for CU-T12-9

References are publications that support the biological activity of the product.

Cheng Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists Sci.Adv. 2015 PMID: 26101787
Cheng Discovery of small molecule inhibitors of the TLR1-TLR2 complex. Angew.Chem.Int.Ed.Engl. 2013 PMID: 22969053