CRT 0105950
Tocris Bioscience, part of Bio-Techne | Catalog # 6273
Potent LIMK1/2 inhibitor
Product Description
CRT 0105950 is a potent LIMK1/2 inhibitor (IC50 values are 0.3 and 1 nM at LIMK 1 and 2, respectively). Disrupts microtubule organization, inhibits cofilin phosphorylation and increases α-tubulin acetylation in vitro.Product Specifications
Molecular Weight
393.89
Formula
C21H16ClN3OS
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[[5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-2-thiazolyl]amino]phenol
CAS Number
1661845-86-8
PubChem ID
117918970
InChI Key
QYDBOFPHPMYWDO-UHFFFAOYSA-N
SMILES
ClC1=C(C2=CN=CC=C2C3=CN=C(NC4=CC=C(O)C=C4)S3)C=CC(C)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.39 | 100 | |
| Ethanol | 19.69 | 50 |
Preparing Stock Solutions
for CRT 0105950
The following data is based on the product molecular weight 393.89
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.54 mL | 12.69 mL | 25.39 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.08 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.54 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mardilovich LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation. Oncotarget. 2015 PMID: 26540348
- Charles Discovery, development, and SAR of aminothiazoles as LIMK inhibitors with cellular anti-invasive properties. J.Med.Chem. 2015 PMID: 26356364
Product Specific Notices for CRT 0105950
For research use only
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