CRBN5-SNAP2-1C-PIP

Tocris Bioscience, part of Bio-Techne | Catalog # 8891

Degrader (PROTAC®) of SNAP-tag™ labeled fusion proteins
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Key Product Details

Description

Degrader (PROTAC®) of SNAP-tag™ labeled fusion proteins

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Product Description

CRBN5-SNAP2-1C-PIP is a Degrader (PROTAC®) of SNAP-tag™ labeled fusion proteins (Dmax = 75% at 1 μM). CRBN5-SNAP2-1C-PIP recruits cereblon E3 ligase to induce the degradation of SNAP-fusion proteins.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

SNAP-tag is a trademark of New England BioLabs, Inc.

Product Specifications

Molecular Weight

646.10

Formula

C32H32ClN7O6

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

N-(4-(((2-Amino-6-chloropyrimidin-4-yl)oxy)methyl)benzyl)-2-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)acetamide

InChI Key

HZTNPAVHBCQKFV-UHFFFAOYSA-N

SMILES

O=C(NCC1=CC=C(COC2=NC(N)=NC(Cl)=C2)C=C1)CC3CCN(C4=CC=C(C(N(C5CCC(NC5=O)=O)C6=O)=O)C6=C4)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 64.61 100

Preparing Stock Solutions for CRBN5-SNAP2-1C-PIP

The following data is based on the product molecular weight 646.10

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.55 mL 7.74 mL 15.48 mL
5 mM 0.31 mL 1.55 mL 3.10 mL
10 mM 0.15 mL 0.77 mL 1.55 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for CRBN5-SNAP2-1C-PIP

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CRBN5-SNAP2-1C-PIP

For research use only

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