CPS2

Name: CPS2
Brand: Tocris Bioscience
SKU: 7800

Tocris Bioscience, part of Bio-Techne | Catalog # 7800

COA / SDS

Potent and selective CDK2 Degrader (PROTAC®)

Key Product Details

Description:	Potent and selective CDK2 Degrader (PROTAC^®)
Chemical Name:	4-[[5-Amino-1-[(3-methyl-2-thienyl)carbonyl]-1H-1,2,4-triazol-3-yl]amino]-N-[2-[[1-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]ethyl]benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	890.95

View Full Technical Details for CPS2

Technical Data
Citations

Biological Activity for CPS2

CPS2 is a potent and selective CDK2 Degrader (PROTAC^®) (IC₅₀ = 24 nM). It induces CDK2 degradation in several AML cell lines, including NB4, U937, OCI-AML2, OCI-AML3 and Kasumi-1 cells. It induces differentiation of AML cell lines, primary AML cells, and granulocytic differentiation of HSCs.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for CPS2

M. Wt	890.95
Formula	C₃₈H₄₂N₁₂O₁₀S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2756741-90-7
PubChem ID	155294157
InChi Key	BXCPYBFBMAWDDY-UHFFFAOYSA-N
Smiles	O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCOCCOCCN4N=NC(COCCNS(=O)(C5=CC=C(NC6=NN(C(C7=C(C)C=CS7)=O)C(N)=N6)C=C5)=O)=C4)=CC=C3)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CPS2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	89.09	100

Preparing Stock Solutions for CPS2

The following data is based on the product molecular weight 890.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.12 mL	5.61 mL	11.22 mL
5 mM	0.22 mL	1.12 mL	2.24 mL
10 mM	0.11 mL	0.56 mL	1.12 mL
50 mM	0.02 mL	0.11 mL	0.22 mL

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References for CPS2

References are publications that support the biological activity of the product.

Wang Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy. Nat.Chem.Biol. 2021 PMID: 33664520