CP 99994 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3417

High affinity NK1 antagonist
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Key Product Details

Description

High affinity NK1 antagonist

View all NK1 Receptor Antagonists »

Product Description

CP 99994 dihydrochloride is a high affinity NK1 antagonist (Ki = 0.145 nM in vitro). Also displays high ex vivo binding potency in gerbil striatum (IC50 = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications

Molecular Weight

369.33

Formula

C19H24N2O.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

(2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinamine dihydrochloride

CAS Number

145148-39-6

PubChem ID

68466923

InChI Key

WNHRFWPLRATIDT-FFUVTKDNSA-N

SMILES

COC(C=CC=C3)=C3CN[C@@H]1[C@H]([C@]2=CC=CC=C2)NCCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 36.93 100
DMSO 18.47 50

Preparing Stock Solutions for CP 99994 dihydrochloride

The following data is based on the product molecular weight 369.33

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.54 mL 27.08 mL
5 mM 0.54 mL 2.71 mL 5.42 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for CP 99994 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CP 99994 dihydrochloride

For research use only

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