CP 945598 hydrochloride

Name: CP 945598 hydrochloride
Brand: Tocris Bioscience
SKU: 4236

Tocris Bioscience, part of Bio-Techne | Catalog # 4236

Citations (2)

COA / SDS

CB1 antagonist

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Product Description
Licensing Information
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

CB1 antagonist

View all Cannabinoid R1/CB1 Antagonists »

Product Description

CP 945598 hydrochloride is a selective, high affinity CB₁ antagonist (K_i values are 0.7 and 0.12 nM in binding and functional assays respectively). Displays low affinity for CB₂ receptors (K_i = 7600 nM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications

Molecular Weight

546.88

Formula

C₂₅H₂₅Cl₂N₇O.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-[8-(2-Chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)piperidine-4-carboxamide hydrochloride

CAS Number

686347-12-6

PubChem ID

16223963

InChI Key

KPYUQCJBZGQHPL-UHFFFAOYSA-N

SMILES

CCNC(CC4)(C(N)=O)CCN4C1=NC=NC2=C1N=C(C5=C(Cl)C=CC=C5)N2C3=CC=C(Cl)C=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.94	20

Preparing Stock Solutions for CP 945598 hydrochloride

The following data is based on the product molecular weight 546.88

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.14 mL	45.71 mL	91.43 mL
1 mM	1.83 mL	9.14 mL	18.29 mL
2 mM	0.91 mL	4.57 mL	9.14 mL
10 mM	0.18 mL	0.91 mL	1.83 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Hadcock In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB₁ receptor antagonist for the management of obesity. Biochem.Biophys.Res.Commun. 2010 PMID: 20211605
Griffith Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. J.Med.Chem. 2009 PMID: 19102698