CP 809101 hydrochloride

Name: CP 809101 hydrochloride
Brand: Tocris Bioscience
SKU: 3041

Tocris Bioscience, part of Bio-Techne | Catalog # 3041

Citations (5)

COA / SDS

Potent and selective 5-HT2C agonist

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective 5-HT2C agonist

View all 5-HT2C Receptor Agonists »

Product Description

CP 809101 hydrochloride is a potent and selective 5-HT_2C receptor agonist (pEC₅₀ values are 9.96, 7.19 and 6.81 for human 5-HT_2C, 5-HT_2B and 5-HT_2A receptors respectively). Displays antipsychotic activity; suppresses condition avoidance responding (CAR) and inhibits PCP and amphetamine-stimulated hyperactivity in rats following subcutaneous administration.

Product Specifications

Molecular Weight

341.24

Formula

C₁₅H₁₇N₄OCl.HCl

Storage

Desiccate at RT

Purity

≥99% (HPLC)

Chemical Name

2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine hydrochloride

CAS Number

1215721-40-6

PubChem ID

56972220

InChI Key

NMUNRTCTDLORDR-UHFFFAOYSA-N

SMILES

ClC1=CC(COC2=NC(N3CCNCC3)=CN=C2)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	6.82	20
	DMSO	34.12	100

Preparing Stock Solutions for CP 809101 hydrochloride

The following data is based on the product molecular weight 341.24

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.93 mL	14.65 mL	29.30 mL
5 mM	0.59 mL	2.93 mL	5.86 mL
10 mM	0.29 mL	1.47 mL	2.93 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

Calculators

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Kalgutkar Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine_2c receptor agonist for the treatment of obesity: role of metabolic activation. Drug Metab.Dispos. 2007 PMID: 17344339
Jensen Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem 2013 PMID: 23301527
Siuciak CP-809,101, a selective 5-HT_2C agonist, shows activity in animal models of antipsychotic activity. Neuropharmacology 2007 PMID: 16949622