CP 690550 citrate is a potent JAK inhibitor (IC₅₀ values are 1, 20, and 112 nM for JAK3, JAK2 and JAK1 respectively). Orally active immunosuppressant; exhibits efficacy in rodent rheumatoid arthritis models.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 690550 (Tofacitinib) is reviewed on the chemical probes website.

Product Specifications

Molecular Weight

504.49

Formula

C₁₆H₂₀N₆O.C₆H₈O₇

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile citrate

CAS Number

540737-29-9

PubChem ID

10174505

InChI Key

SYIKUFDOYJFGBQ-YLAFAASESA-N

SMILES

C[C@H]1[C@@H](N(C2=NC=NC3=C2C=CN3)C)CN(C(CC#N)=O)CC1.OC(CC(O)=O)(C(O)=O)CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	50.45	100

Preparing Stock Solutions for CP 690550 citrate

The following data is based on the product molecular weight 504.49

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.98 mL	9.91 mL	19.82 mL
5 mM	0.40 mL	1.98 mL	3.96 mL
10 mM	0.20 mL	0.99 mL	1.98 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Flanagan Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection. J.Med.Chem. 2010 PMID: 21105711
Dowty Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis. J.Pharmacol.Exp.Ther. 2013 PMID: 24218541
Jiang Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550). J.Med.Chem. 2008 PMID: 19053756

CP 690550 citrate

Tocris Bioscience, part of Bio-Techne | Catalog # 4556

Key Product Details

Description

Alternative Names

View all JAK Kinase Inhibitors »

Product Description