CP 339818 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1399
Non-peptide, potent KV1.3 channel blocker
Discontinued Product
1399 has been discontinued.
View all Voltage-gated Potassium Channel Blockers products.
Key Product Details
Description
Non-peptide, potent KV1.3 channel blocker
Product Description
CP 339818 hydrochloride is a potent, non-peptide KV1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel (IC50 ~ 200 nM) . Inhibits KV1.4 with an IC50 of ~ 300 nM. Selective over KV1.1, KV1.2, KV1.5, KV1.6, KV3.1-4, and KV4.2.Product Specifications
Molecular Weight
340.89
Formula
C21H24N2.HCl
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
N-[1-(Phenylmethyl)-4(1H)-quinolinylidene]-1 pentanamine hydrochloride
CAS Number
478341-55-8
PubChem ID
20761468
InChI Key
JIRISCAPZWLWCG-UHFFFAOYSA-N
SMILES
CCCCC\N=C2C1=CC=CC=C1N(CC3=CC=CC=C3)C=C/2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 20 |
Preparing Stock Solutions
for CP 339818 hydrochloride
The following data is based on the product molecular weight 340.89
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.67 mL | 73.34 mL | 146.67 mL |
| 1 mM | 2.93 mL | 14.67 mL | 29.33 mL |
| 2 mM | 1.47 mL | 7.33 mL | 14.67 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.93 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nguyen Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol.Pharmacol. 1996 PMID: 8967992
- Jager Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated. J.Physiol. 1998 PMID: 9490854
Product Specific Notices for CP 339818 hydrochloride
For research use only
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