Co 101244 hydrochloride

Name: Co 101244 hydrochloride
Brand: Tocris Bioscience
SKU: 2456
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2456

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Citations (40)

COA / SDS

GluN2B-selective NMDA antagonist

Key Product Details

Description:	GluN2B-selective NMDA antagonist
Alternative Names:	PD 174494,Ro 63-1908
Chemical Name:	1-[2-(4-Hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-4-piperidinol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	377.91

View Full Technical Details for Co 101244 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Co 101244 hydrochloride

Co 101244 hydrochloride is a novel, potent and selective antagonist of GluN2B (formally NR2B)-containing NMDA receptors (IC₅₀ values are 0.043, > 100 and > 100 μM for GluN1A/2B (NR1A/2B), GluN1A/2A (NR1A/2A) and GluN1A/2C (NR1A/2C) subunit combinations respectively). Displays neuroprotective effects in vivo and in vitro.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Compound Libraries for Co 101244 hydrochloride

Co 101244 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Co 101244 hydrochloride

M. Wt	377.91
Formula	C₂₁H₂₇NO₃.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	193356-17-1
PubChem ID	6918426
InChi Key	WFFZHKKSIDENAJ-UHFFFAOYSA-N
Smiles	Cl.CC1=CC=C(CC2(O)CCN(CCOC3=CC=C(O)C=C3)CC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Co 101244 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	37.79	100
	DMSO	18.9	50

Preparing Stock Solutions for Co 101244 hydrochloride

The following data is based on the product molecular weight 377.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.23 mL	26.46 mL
5 mM	0.53 mL	2.65 mL	5.29 mL
10 mM	0.26 mL	1.32 mL	2.65 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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References for Co 101244 hydrochloride

References are publications that support the biological activity of the product.

Gill Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-MthD.-aspartate antagonist. J.Pharmacol.Exp.Ther. 2002 PMID: 12183650
Higgins Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition. Neuropharmacology 2003 PMID: 12604092
Zhou 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J.Med.Chem. 1999 PMID: 10425109