CM 10

Name: CM 10
Brand: Tocris Bioscience
SKU: 6933

Tocris Bioscience, part of Bio-Techne | Catalog # 6933

Citations (9)

COA / SDS

ALDH1A inhibitor; depletes CD133+ cancer stem cells

Discontinued Product

6933 has been discontinued. View all Aldehyde Dehydrogenase Inhibitors products.

Key Product Details

Description:	ALDH1A inhibitor; depletes CD133⁺ cancer stem cells
Chemical Name:	2-(2-Propen-1-yl)-6-[[(1-propyl-1H-benzimidazol-2-yl)amino]methyl]phenol
Purity:	≥98% (HPLC)
Molecular Weight:	321.42

View Full Technical Details for CM 10

Technical Data
Citations

Biological Activity for CM 10

CM 10 is a aldehyde dehydrogenase 1A (ALDH1A) inhibitor (IC₅₀ values are 0.64, 0.74 and 1.7 μM for ALDH1A3, ALDH1A2 and ALDH1A1, respectively). Induces a necroptotic phenotype and preferentially depletes CD133⁺ ovarian cancer stem cells in vitro.

Technical Data for CM 10

M. Wt	321.42
Formula	C₂₀H₂₃N₃O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	692269-09-3
PubChem ID	889692
InChi Key	ZFHWEWJDCFGRBO-UHFFFAOYSA-N
Smiles	CCCN1C(NCC2=C(O)C(CC=C)=CC=C2)=NC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for CM 10

References are publications that support the biological activity of the product.

Morgan & Hurley Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1. Chem.Biol.Interact. 2015 PMID: 25450233
Chefetz A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells. Cell Rep. 2019 PMID: 30865894

CM 10

Tocris Bioscience, part of Bio-Techne | Catalog # 6933

Key Product Details

Biological Activity for CM 10

Technical Data for CM 10

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for CM 10

Product Documents for CM 10

COA

Certificate of Analysis

SDS

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