Clozapine

Tocris Bioscience, part of Bio-Techne | Catalog # 0444

Dopamine antagonist with some D4 selectivity; also 5-HT2A/2C antagonist
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Key Product Details

Description

Dopamine antagonist with some D4 selectivity; also 5-HT2A/2C antagonist

View all Non-selective Dopamine Receptor Antagonists »

Product Description

Clozapine is an atypical antipsychotic drug, with a much lower tendency to cause extrapyramidal side effects than conventional neuroleptics. Displays a broad range of pharmacological actions; the antipsychotic effects are thought to be mediated principally by 5-HT2A/2C and dopamine receptor blockade (Ki values are 21, 170, 170, 230 and 330 nM for D4, D3, D1, D2 and D5 receptors respectively).

Product Specifications

Molecular Weight

326.83

Formula

C18H19ClN4

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

CAS Number

5786-21-0

PubChem ID

2818

InChI Key

ZUXABONWMNSFBN-UHFFFAOYSA-N

SMILES

CN1CCN(CC1)C1=NC2=C(NC3=C1C=CC=C3)C=CC(Cl)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
2eq.HCl 16.34 50 with gentle warming
DMSO 32.68 100

Preparing Stock Solutions for Clozapine

The following data is based on the product molecular weight 326.83

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.06 mL 15.30 mL 30.60 mL
5 mM 0.61 mL 3.06 mL 6.12 mL
10 mM 0.31 mL 1.53 mL 3.06 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

Calculators

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Product Documents for Clozapine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Clozapine

For research use only

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