CK 666

Name: CK 666
Brand: Tocris Bioscience
SKU: 3950

Tocris Bioscience, part of Bio-Techne | Catalog # 3950

Citations (105)

COA / SDS

Arp2/3 inhibitor; inhibits actin polymerization

Key Product Details

Description:	Arp2/3 inhibitor; inhibits actin polymerization
Chemical Name:	2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	296.34

View Full Technical Details for CK 666

Technical Data
Citations

Biological Activity for CK 666

CK 666 is an inhibitor of the Arp2/3 complex; inhibits actin polymerization (IC₅₀ = 4 μM).

Technical Data for CK 666

M. Wt	296.34
Formula	C₁₈H₁₇FN₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	442633-00-3
PubChem ID	589075
InChi Key	UXRKUKRXVWJFER-UHFFFAOYSA-N
Smiles	FC1=CC=CC=C1C(NCCC2=C(C)NC3=C2C=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CK 666

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.63	100
	ethanol	29.63	100

Preparing Stock Solutions for CK 666

The following data is based on the product molecular weight 296.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.37 mL	16.87 mL	33.75 mL
5 mM	0.67 mL	3.37 mL	6.75 mL
10 mM	0.34 mL	1.69 mL	3.37 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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References for CK 666

References are publications that support the biological activity of the product.

Han and Nolen X-ray crystal structures and molecular mechanism of improved Arp2/3 complex inhibitors. 1751 ACSB 2009 Abstracts. American Society for Cel
Nolen Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 2009 PMID: 19648907