CK 666
Tocris Bioscience, part of Bio-Techne | Catalog # 3950
Arp2/3 inhibitor; inhibits actin polymerization
Key Product Details
Description
Arp2/3 inhibitor; inhibits actin polymerization
Product Description
CK 666 is an inhibitor of the Arp2/3 complex; inhibits actin polymerization (IC50 = 4 μM).Product Specifications
Molecular Weight
296.34
Formula
C18H17FN2O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
CAS Number
442633-00-3
PubChem ID
589075
InChI Key
UXRKUKRXVWJFER-UHFFFAOYSA-N
SMILES
FC1=CC=CC=C1C(NCCC2=C(C)NC3=C2C=CC=C3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.63 | 100 | |
| Ethanol | 29.63 | 100 |
Preparing Stock Solutions
for CK 666
The following data is based on the product molecular weight 296.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.37 mL | 16.87 mL | 33.75 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.75 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.37 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Han and Nolen X-ray crystal structures and molecular mechanism of improved Arp2/3 complex inhibitors. 1751 ACSB 2009 Abstracts. American Society for Cel
- Nolen Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 2009 PMID: 19648907
Product Specific Notices for CK 666
For research use only
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