CITCO

Tocris Bioscience, part of Bio-Techne | Catalog # 3683

Selective CAR agonist
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Key Product Details

Description

Selective CAR agonist

View all VDR-like Receptor Agonists »

Product Description

CITCO is a constitutive androstane receptor (CAR) agonist (EC50 = 49 nM). Displays > 100-fold selectivity over PXR receptors and no activity at LXR, ERα, ERβ, PPAR, RAR, FXR, VDR and THR. Induces CAR nuclear translocation and expression of CYP2B6 in hepatocytes in vitro.

Product Specifications

Molecular Weight

436.74

Formula

C19H12Cl3N3OS

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime

CAS Number

338404-52-7

PubChem ID

9600409

InChI Key

ZQWBOKJVVYNKTL-AUEPDCJTSA-N

SMILES

ClC(C(Cl)=C4)=CC=C4CO/N=C/C1=C(C3=CC=C(Cl)C=C3)N=C2N1C=CS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.84 50

Preparing Stock Solutions for CITCO

The following data is based on the product molecular weight 436.74

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.58 mL 22.90 mL 45.79 mL
2.5 mM 0.92 mL 4.58 mL 9.16 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
25 mM 0.09 mL 0.46 mL 0.92 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for CITCO

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CITCO

For research use only

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