Citalopram hydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 1427
Highly potent and selective 5-HT uptake inhibitor
Key Product Details
Description
Highly potent and selective 5-HT uptake inhibitor
Product Description
Citalopram hydrobromide is a highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake (IC50 values are 1.8, 8800 and 41000 nM respectively). Has negligible activity at a wide range of receptors.Product Specifications
Molecular Weight
405.31
Formula
C20H21FN2O.HBr
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
CAS Number
59729-32-7
PubChem ID
77995
InChI Key
WIHMBLDNRMIGDW-UHFFFAOYSA-N
SMILES
Br.CN(C)CCCC1(OCC2=C1C=CC(=C2)C#N)C1=CC=C(F)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 10 | ||
| Ethanol | 50 |
Preparing Stock Solutions
for Citalopram hydrobromide
The following data is based on the product molecular weight 405.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.93 mL | 24.67 mL | 49.34 mL |
| 2.5 mM | 0.99 mL | 4.93 mL | 9.87 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.93 mL |
| 25 mM | 0.10 mL | 0.49 mL | 0.99 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mateo Inhibition of 5-hydroxytryptamine reuptake by the antidepressant cital. in the locus coeruleus modulates the rat brain noradrenergic transmission in vivo. Neuropharmacology 2000 PMID: 10963747
- Hyttel Citalopram - pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog.Drug Metabolism. Eds. Bridges, J. W. & Ch
- Auerbach and Hjorth Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor cital. on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo. Naunyn Schmiedebergs Arch.Pharmacol. 1995 PMID: 9053730
Product Specific Notices for Citalopram hydrobromide
For research use only
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