cis-22a
Tocris Bioscience, part of Bio-Techne | Catalog # 7118
TRPV6 inhibitor
Product Description
cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.Product Specifications
Molecular Weight
563.54
Formula
C22H29N3.2CF3CO2H
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-[cis-4-(3-Methylphenyl)cyclohexyl]-4-(3-pyridinyl)piperazine ditrifluoroacetate
CAS Number
1819366-84-1
InChI Key
UMKPISXYUQWXJJ-XWOHEVPJSA-N
SMILES
CC1=CC=CC([C@@H]2CC[C@H](N3CCN(C4=CN=CC=C4)CC3)CC2)=C1.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 56.35 | 100 | |
| DMSO | 56.35 | 100 |
Preparing Stock Solutions
for cis-22a
The following data is based on the product molecular weight 563.54
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.77 mL | 8.87 mL | 17.74 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.55 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.77 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Simonin Optimization of TRPV6 calcium channel inhibitors using a 3D ligand-based virtual screening method. Angew.Chem.Int.Ed.Engl. 2015 PMID: 26457814
- Cunha Photoswitchable inhibitor of the calcium channel TRPV6. ACS Med.Chem.Lett. 2019 PMID: 31531207
Product Specific Notices for cis-22a
For research use only
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