Cinanserin hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0460
Selective 5-HT2 antagonist; also 3C-like proteinase inhibitor
Discontinued Product
0460 has been discontinued.
View all Non-selective 5-HT2 Receptor Antagonists products.
Key Product Details
Description
Selective 5-HT2 antagonist; also 3C-like proteinase inhibitor
Product Description
Cinanserin hydrochloride is a 5-HT2 antagonist. Also inhibits 3C-like proteinase (3CLpro; Mpro). Inhibits replication of SARS-CoV.Product Specifications
Molecular Weight
376.94
Formula
C20H24N2OS.HCl
Storage
Desiccate at RT
Purity
≥99% (HPLC)
Chemical Name
N-[2-[[3-(Dimethylamino)propyl]thio]phenyl]-3-phenyl-2-propenamide hydrochloride
CAS Number
54-84-2
PubChem ID
6433141
InChI Key
LXGJPDKYMJJWRB-IERUDJENSA-N
SMILES
O=C(/C=C/C2=CC=CC=C2)NC1=CC=CC=C1SCCCN(C)C.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 50 |
Preparing Stock Solutions
for Cinanserin hydrochloride
The following data is based on the product molecular weight 376.94
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.31 mL | 26.53 mL | 53.06 mL |
| 2.5 mM | 1.06 mL | 5.31 mL | 10.61 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.31 mL |
| 25 mM | 0.11 mL | 0.53 mL | 1.06 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pierce Molecular structure basis of ligand selectivity for 5-HT2 versus 5-HT1C cortical receptors. Naunyn Schmiedebergs Arch.Pharmacol. 1992 PMID: 1407003
- Chen Cinanserin is an inhibitor of the 3C-like proteinase of the severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J.Virol. 2005 PMID: 15890949
- Leysen Receptor binding profile of R-41-468, a novel antagonist at 5HT2 receptors. Life Sci. 1981 PMID: 6261070
Product Specific Notices for Cinanserin hydrochloride
For research use only
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