CIMBA hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 7812
Potent and selective G protein-coupled estrogen receptor (GPER) antagonist
Key Product Details
Description
Potent and selective G protein-coupled estrogen receptor (GPER) antagonist
Product Description
CIMBA hydrochloride is a potent G protein-coupled estrogen receptor (GPER) antagonist (IC50 = 75 nM). In vivo, it prevents the formation of estrogen-induced cholesterol gallstones by inhibiting the GPER pathway in female ovariectomized mice.Licensing Information
Sold under licence from Saint Louis University.Product Specifications
Molecular Weight
373.97
Formula
C23H31NO.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-Cyclohexyl-4-(1-methylethyl)phenyl]-4-methoxybenzenemethanamine hydrochloride
InChI Key
KWVXXQOTMDKOID-UHFFFAOYSA-N
SMILES
CC(C)C(C=C1C2CCCCC2)=CC=C1NCC(C=C3)=CC=C3OC.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.4 | 100 | |
| Ethanol | 37.4 | 100 |
Preparing Stock Solutions
for CIMBA hydrochloride
The following data is based on the product molecular weight 373.97
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.67 mL | 13.37 mL | 26.74 mL |
| 5 mM | 0.53 mL | 2.67 mL | 5.35 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.67 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- DeLeon A novel GPER antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice. J.Lipid Res. 2020 PMID: 32127396
Product Specific Notices for CIMBA hydrochloride
For research use only
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