Cilengitide

Tocris Bioscience, part of Bio-Techne | Catalog # 5870

Potent and selective inhibitor of integrins αvβ3 and αvβ5
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Key Product Details

Description

Potent and selective inhibitor of integrins αvβ3 and αvβ5

Alternative Names

EMD121974

View all Integrin Receptor Inhibitors »

Product Description

Cilengitide is a potent and selective inhibitor of integrins αvβ3 and αvβ5 (IC50 values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.

Product Specifications

Molecular Weight

588.66

Formula

C27H40N8O7

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

188968-51-6

PubChem ID

176873

InChI Key

AMLYAMJWYAIXIA-VWNVYAMZSA-N

SMILES

CC(C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 10mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Product Documents for Cilengitide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Cilengitide

For research use only

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