Ciclopirox
Tocris Bioscience, part of Bio-Techne | Catalog # 6384
Pan-histone demethylase inhibitor
Key Product Details
Description
Pan-histone demethylase inhibitor
Product Description
Ciclopirox is a pan-histone demethylase inhibitor. Exhibits no significant effect on histone deacetylases. Inhibits MYC-signaling and proliferation of neuroblastoma cells. Promotes Cdc25A-degradation in cancer cells. Antifungal.Product Specifications
Molecular Weight
207.27
Formula
C12H17NO2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone
CAS Number
29342-05-0
PubChem ID
2749
InChI Key
SCKYRAXSEDYPSA-UHFFFAOYSA-N
SMILES
CC1=CC(N(C(C2CCCCC2)=C1)O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.73 | 100 | |
| Ethanol | 20.73 | 100 |
Preparing Stock Solutions
for Ciclopirox
The following data is based on the product molecular weight 207.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.82 mL | 24.12 mL | 48.25 mL |
| 5 mM | 0.96 mL | 4.82 mL | 9.65 mL |
| 10 mM | 0.48 mL | 2.41 mL | 4.82 mL |
| 50 mM | 0.10 mL | 0.48 mL | 0.96 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yang Targeting histone demethylases in MYC-driven neuroblastomas with ciclopirox. Cancer Res. 2017 PMID: 28684529
- Shen Ciclopirox inhibits cancer cell proliferation by suppression of Cdc25A. Genes Cancer 2017 PMID: 28680535
Product Specific Notices for Ciclopirox
For research use only
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