CIA 1
Tocris Bioscience, part of Bio-Techne | Catalog # 7494
COUP-TFII inhibitor
Product Description
CIA 1 is an inhibitor of the nuclear receptor COUP-TFII (IC50 ranged from 1.2 μM to 7.6 μM, in prostate cancer cell lines). In vitro, CIA 1 inhibits growth of multiple prostate cancer cell lines and suppresses COUP-TFII activity to regulate its target genes. In vivo, CIA 1 reduces tumor growth in prostate cancer xenograft mouse models.Product Specifications
Molecular Weight
365.88
Formula
C17H19N3O2S.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(3,4-Dimethoxyphenyl)ethyl]-6-methylthieno[2,3-d]pyrimidin-4-amine hydrochloride
CAS Number
1049691-47-5
PubChem ID
2974648
InChI Key
PYRMFONFWQTEGD-UHFFFAOYSA-N
SMILES
COC1=C(C=C(C=C1)CCNC2=C3C=C(SC3=NC=N2)C)OC.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.32 | 20 |
Preparing Stock Solutions
for CIA 1
The following data is based on the product molecular weight 365.88
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.67 mL | 68.33 mL | 136.66 mL |
| 1 mM | 2.73 mL | 13.67 mL | 27.33 mL |
| 2 mM | 1.37 mL | 6.83 mL | 13.67 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci.Adv. 2020 PMID: 32494682
Product Specific Notices for CIA 1
For research use only
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