CI 994

Name: CI 994
Brand: Tocris Bioscience
SKU: 2952

Tocris Bioscience, part of Bio-Techne | Catalog # 2952

COA / SDS

Class I histone deacetylase inhibitor; orally active

Discontinued Product

2952 has been discontinued. View all Class I Histone Deacetylases Inhibitors products.

Key Product Details

Description:	Class I histone deacetylase inhibitor; orally active
Alternative Names:	N-acetyldinaline
Chemical Name:	4-(Acetylamino)-N-(2-aminophenyl)benzamide
Purity:	≥99% (HPLC)
Molecular Weight:	269.3

View Full Technical Details for CI 994

Technical Data
Citations

Biological Activity for CI 994

CI 994 is an orally active class I histone deacetylase (HDAC) inhibitor (K_i values are 0.41, 0.75, >100 and >100 μM for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G₁ cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo. Increases neuroplasticity during memory extinction. Also increases efficiency of hepatic differentiation of hPSCs

Compound Libraries for CI 994

CI 994 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for CI 994

M. Wt	269.3
Formula	C₁₅H₁₅N₃O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	112522-64-2
PubChem ID	2746
InChi Key	VAZAPHZUAVEOMC-UHFFFAOYSA-N
Smiles	O=C(NC2=C(N)C=CC=C2)C1=CC=C(NC(C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for CI 994

References are publications that support the biological activity of the product.

Gräff Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell 2014 PMID: 24439381
Kraker Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benamide] in HCT-8 colon carcinoma. Mol.Cancer Ther. 2003 PMID: 12700284
Beckers Distinct pharamacologcial properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. Int.J.Cancer 2007 PMID: 17455259