CHR 2797
Tocris Bioscience, part of Bio-Techne | Catalog # 3595
Aminopeptidase inhibitor
Key Product Details
Description
Aminopeptidase inhibitor
Alternative Names
Tosedostat
Product Description
CHR 2797 is an aminopeptidase inhibitor (IC50 values are 100, 150, 220, > 1000, > 5000, > 10000 and > 30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2, respectively). Potently inhibits tumor cell proliferation in a variety of tumor cell lines in vitro and in vivo. Also inhibits neprilysin (IC50 = 900 nM). Exhibits antinociceptive activity and enhances the efficacy of Morphine (Cat. No. 5158) in the hot-plate and tail-flick assays, via an action on the peripheral nervous system.Product Specifications
Molecular Weight
406.48
Formula
C21H30N2O6
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
α-[[(2R)-2-[(1S)-1-Hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]-benzeneacetic acid cyclopently ester
CAS Number
238750-77-1
PubChem ID
15547703
InChI Key
FWFGIHPGRQZWIW-SQNIBIBYSA-N
SMILES
O=C([C@H]([C@]2=CC=CC=C2)NC([C@@H]([C@@H](C(NO)=O)O)CC(C)C)=O)OC1CCCC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.65 | 100 | |
| Ethanol | 20.32 | 50 |
Preparing Stock Solutions
for CHR 2797
The following data is based on the product molecular weight 406.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.46 mL | 12.30 mL | 24.60 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.92 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Moore Aminopeptidase inhibition as a targeted treatment strategy in myeloma. Mol.Cancer Ther. 2009 PMID: 19372548
- Singh Discovery of anticancer clinical candidate, Tosedostat, as an analgesic agent. ACS Chem.Neurosci. 2019 PMID: 31415151
- Krige CHR-2797: an anitproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer Res. 2008 PMID: 18701491
Product Specific Notices for CHR 2797
For research use only
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