CHIR 99021 in solution
Tocris Bioscience, part of Bio-Techne | Catalog # 8170
Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO
Key Product Details
Description
Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO
Product Description
CHIR 99021 in solution is a convenient and ready-to-use 10 mM sterile-filtered solution of CHIR 99021 (Cat. No. 4423) pre-dissolved in DMSO. A potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3) (IC50 values are 6.7 and 10 nM for GSK-3β and GSK-3α respectively). Acts as Wnt activator. In combination with the irreversible inhibitor of LSD1, Tranylcypromine (Cat. No. 3852), CHIR 99021 enables reprogramming of mouse embryonic fibroblasts into iPSCs. Enhances mouse and human ESC self-renewal when used in combination with PD 0325901 (Cat. No. 4192); promotes differentiation of hPSCs in cardiomyocytes and allows formation of extended pluripotent stem (EPS) cells in combination with (S)-(+)-Dimethindene maleate (Cat. No. 1425), Minocycline (Cat. No. 3268) and human leukemia inhibitory factor.CHIR 99021 synthesized to cGMP guidelines also available.
Product Specifications
Molecular Weight
465.34
Formula
C22H18Cl2N8
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
CAS Number
252917-06-9
PubChem ID
9956119
InChI Key
AQGNHMOJWBZFQQ-UHFFFAOYSA-N
SMILES
ClC(C=C1Cl)=CC=C1C2=NC(NCCNC3=CC=C(C#N)C=N3)=NC=C2C4=NC=C(C)N4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Calculators
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Background References
References are publications that support the biological activity of the product.
Product Specific Notices for CHIR 99021 in solution
For research use only
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