Chelerythrine chloride

Product Description

Chelerythrine chloride is a cell-permeable inhibitor of protein kinase C (IC₅₀ = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of Bcl_XL to Bak (IC₅₀ = 1.5 μM) or Bad proteins and stimulates apoptosis.

Solubility

Preparing Stock Solutions for Chelerythrine chloride

The following data is based on the product molecular weight 383.83

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.05 mL	130.27 mL	260.53 mL
0.5 mM	5.21 mL	26.05 mL	52.11 mL
1 mM	2.61 mL	13.03 mL	26.05 mL
5 mM	0.52 mL	2.61 mL	5.21 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Yu Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. J.Biol.Chem. 2000 PMID: 10734112
• Herbert Chelerythrine is a potent and specfic inhibitor of protein kinase C. Biochem.Biophys.Res.Commun. 1990 PMID: 2244923
• Lee Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C. J.Biol.Chem. 1998 PMID: 9677417
• Chan Identification of chelerythrine as an inhibitor of BclXL function. J.Biol.Chem. 2003 PMID: 12702731