CHDI 00390576

Tocris Bioscience, part of Bio-Techne | Catalog # 6725

Potent and selective class IIa HDAC inhibitor; brain penetrant
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Key Product Details

Description

Potent and selective class IIa HDAC inhibitor; brain penetrant

View all Histone Deacetylase Inhibitors »

Product Description

CHDI 00390576 is a potent and selective class IIa histone deacetylase (HDAC) inhibitor (IC50 values are 31, 50, 54 and 60 nM for HDAC7, HDAC9, HDAC4 and HDAC5, respectively). Displays >100-fold selectivity for class IIa HDACs over other HDACs. Brain penetrant.

Licensing Information

Sold under license from CHDI Foundation

Product Specifications

Molecular Weight

391.32

Formula

C19H13F4N3O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-(2-Fluorophenyl)-N-hydroxy-2-(4-(5-(trifluoromethyl)pyrimidin-2-yl)phenyl)acetamide

CAS Number

1629729-98-1

PubChem ID

81689842

InChI Key

LMGDHGQJJLEAPQ-UHFFFAOYSA-N

SMILES

ONC(C(C1=C(C=CC=C1)F)C2=CC=C(C3=NC=C(C(F)(F)F)C=N3)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.13 100
Ethanol 39.13 100

Preparing Stock Solutions for CHDI 00390576

The following data is based on the product molecular weight 391.32

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.78 mL 25.55 mL
5 mM 0.51 mL 2.56 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for CHDI 00390576

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CHDI 00390576

For research use only

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