CGP 53353

Name: CGP 53353
Brand: Tocris Bioscience
SKU: 2442

Tocris Bioscience, part of Bio-Techne | Catalog # 2442

Citations (19)

COA / SDS

Selective inhibitor of PKCβII

Key Product Details

Description:	Selective inhibitor of PKCβII
Chemical Name:	5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	365.34

View Full Technical Details for CGP 53353

Technical Data
Citations

Biological Activity for CGP 53353

CGP 53353 is a selective inhibitor of PKCβII (IC₅₀ values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively). Also inhibits prionogenic Sup35 fibrillization (IC₅₀ ~ 3.4 μM) and inhibits de novo Aβ42 assembly in vitro.

Compound Libraries for CGP 53353

CGP 53353 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for CGP 53353

M. Wt	365.34
Formula	C₂₀H₁₃F₂N₃O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	145915-60-2
PubChem ID	6711154
InChi Key	RONQPWQYDRPRGG-UHFFFAOYSA-N
Smiles	FC1=CC=C(NC2=CC3=C(C=C2NC2=CC=C(F)C=C2)C(=O)NC3=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 53353

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.53	100
	ethanol	7.31	20

Preparing Stock Solutions for CGP 53353

The following data is based on the product molecular weight 365.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.69 mL	27.37 mL
5 mM	0.55 mL	2.74 mL	5.47 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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References for CGP 53353

References are publications that support the biological activity of the product.

Wang Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci.USA
Kouroedov Selective inhibition of protein kinase Cβ2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 2004 PMID: 15210597