CGP 52411

Name: CGP 52411
Brand: Tocris Bioscience
SKU: 3360

Tocris Bioscience, part of Bio-Techne | Catalog # 3360

COA / SDS

EGFR inhibitor. Also inhibits Aβ42 fibril formation

Discontinued Product

3360 has been discontinued. View all EGF Receptor Inhibitors products.

Key Product Details

Description:	EGFR inhibitor. Also inhibits Aβ42 fibril formation
Alternative Names:	DAPH
Chemical Name:	5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione
Purity:	≥99% (HPLC)
Molecular Weight:	329.35

View Full Technical Details for CGP 52411

Technical Data
Citations

Biological Activity for CGP 52411

CGP 52411 is a selective inhibitor of the epidermal growth factor receptor (EGFR) (IC₅₀ = 0.3 μM in vitro). Also inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease. Eliminates calcium influx potential when coincubated with amyloid β-peptide (1-42) (Cat.No. 1428); reduces neurotoxicity by blocking Ca²⁺ influx into neuronal cells.

Technical Data for CGP 52411

M. Wt	329.35
Formula	C₂₀H₁₅N₃O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	145915-58-8
PubChem ID	1697
InChi Key	AAALVYBICLMAMA-UHFFFAOYSA-N
Smiles	O=C2NC(C1=CC(NC4=CC=CC=C4)=C(NC3=CC=CC=C3)C=C12)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for CGP 52411

References are publications that support the biological activity of the product.

Blanchard Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule. Proc.Natl.Acad.Sci. 2004 PMID: 15388848
Wang Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci. 2008 PMID: 18480256
Buchdunger 4,5-dianilinophthalimide: a protein tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity. Proc.Natl.Acad.Sci. 1994 PMID: 8134396

CGP 52411

Tocris Bioscience, part of Bio-Techne | Catalog # 3360

Key Product Details

Biological Activity for CGP 52411

Technical Data for CGP 52411

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for CGP 52411

Product Documents for CGP 52411

COA

Certificate of Analysis

SDS

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