CGP 20712 dihydrochloride

Name: CGP 20712 dihydrochloride
Brand: Tocris Bioscience
SKU: 1024

Tocris Bioscience, part of Bio-Techne | Catalog # 1024

Citations (37)

COA / SDS

Highly potent and selective β1 antagonist

Key Product Details

Description:	Highly potent and selective β₁ antagonist
Chemical Name:	1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy]-2-propanol dihydrochloride
Purity:	≥96% (HPLC)
Molecular Weight:	567.39

View Full Technical Details for CGP 20712 dihydrochloride

Technical Data
Citations

Biological Activity for CGP 20712 dihydrochloride

CGP 20712 dihydrochloride is a highly selective and potent β₁-adrenoceptor antagonist (IC₅₀ = 0.7 nM). Displays 10,000-fold selectivity over β₂-adrenoceptors.

Technical Data for CGP 20712 dihydrochloride

M. Wt	567.39
Formula	C₂₃H₂₅F₃N₄O₅.2HCl
Storage	Store at +4°C
Purity	≥96% (HPLC)
CAS Number	1216905-73-5
PubChem ID	56972164
InChi Key	PURFQCFKYNMIQF-UHFFFAOYSA-N
Smiles	Cl.Cl.CN1C=C(N=C1C1=CC=C(OCC(O)CNCCOC2=CC=C(O)C(=C2)C(N)=O)C=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 20712 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	24.72	50

Preparing Stock Solutions for CGP 20712 dihydrochloride

The following data is based on the product molecular weight 567.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.52 mL	17.62 mL	35.25 mL
2.5 mM	0.70 mL	3.52 mL	7.05 mL
5 mM	0.35 mL	1.76 mL	3.52 mL
25 mM	0.07 mL	0.35 mL	0.70 mL

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References for CGP 20712 dihydrochloride

References are publications that support the biological activity of the product.

Hieble α-and β-adrenoceptors. From the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 1995 PMID: 7658428
Kitagawa Determination of β-adrenoceptor subtype on rat isolated ventricular myocytes by use of highly selective β-antagonists. Br.J.Pharmacol. 1995 PMID: 8564230
Dooley CGP 20712A: a useful tool for quantitating β₁- and β₂-adrenoceptors. Eur.J.Pharmacol. 1986 PMID: 2877892