Cevimeline hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3689
Selective M1 agonist
Key Product Details
Description
Selective M1 agonist
Alternative Names
AF 102B,SNI 2011
Product Description
Cevimeline hydrochloride is a selective M1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC50 values are 3.5 and 3 μM respectively). Reverses AF64A-induced cognitive impairments in vivo.Product Specifications
Molecular Weight
235.77
Formula
C10H17NOS.HCl
Storage
Store at -20°C
Chemical Name
cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride
CAS Number
107220-28-0
PubChem ID
76965955
InChI Key
SKFLGMLYGHWKJG-RXUMEZLZSA-N
SMILES
C[C@@H](SC3)O[C@@]13CN2CCC1CC2.C[C@H](SC6)O[C@]46CN5CCC4CC5.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 17.68 | 75 | |
| DMSO | 11.79 | 50 |
Preparing Stock Solutions
for Cevimeline hydrochloride
The following data is based on the product molecular weight 235.77
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 5.66 mL | 28.28 mL | 56.55 mL |
| 3.75 mM | 1.13 mL | 5.66 mL | 11.31 mL |
| 7.5 mM | 0.57 mL | 2.83 mL | 5.66 mL |
| 37.5 mM | 0.11 mL | 0.57 mL | 1.13 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fisher (+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J.Pharmacol.Exp.Ther. 1991 PMID: 2019998
- Hargreaves L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors. Br.J.Pharmacol. 1992 PMID: 1422595
- Wanibuchi Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954. Eur.J.Pharmacol. 1990 PMID: 1963596
Product Specific Notices for Cevimeline hydrochloride
For research use only
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