Cerulenin

Name: Cerulenin
Brand: Tocris Bioscience
SKU: 6702

Tocris Bioscience, part of Bio-Techne | Catalog # 6702

COA / SDS

Irreversible fatty acid synthase inhibitor

Discontinued Product

6702 has been discontinued. View all Fatty Acid Synthase Inhibitors products.

Key Product Details

Description:	Irreversible fatty acid synthase inhibitor
Chemical Name:	(2R,3S)-3-[(4E,7E)-1-Oxo-4,7-nonadien-1-yl]-2-oxiranecarboxamide
Molecular Weight:	223.27

View Full Technical Details for Cerulenin

Technical Data
Citations

Biological Activity for Cerulenin

Cerulenin is an irreversible fatty acid synthase inhibitor. Blocks proliferation of KRAS-driven lung cancer cells. Promotes apoptosis and inhibits necroptosis in cancer cells. Also inhibits protein palmitoylation and insulin uptake in rat adipocytes in vitro. Antibiotic.

Technical Data for Cerulenin

M. Wt	223.27
Formula	C₁₂H₁₇NO₃
Storage	Store at -20°C
CAS Number	17397-89-6
PubChem ID	5282054
InChi Key	GVEZIHKRYBHEFX-NQQPLRFYSA-N
Smiles	C/C=C/C/C=C/CCC([C@H]1O[C@H]1C(N)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Cerulenin

References are publications that support the biological activity of the product.

Parisi Very long chain fatty acids are functionally involved in necroptosis. Cell Chem.Bio. 2017 PMID: 29033315
Jochen Inhibitory effects of cerulenin on protein palmitoylation and Ins internalization in rat adipocytes. Biochim.Biophys.Acta. 1995 PMID: 7492617
Gouw Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma. Proc.Natl.Acad.Sci.U.S.A. 2017 PMID: 28400509

Cerulenin

Tocris Bioscience, part of Bio-Techne | Catalog # 6702

Key Product Details

Biological Activity for Cerulenin

Technical Data for Cerulenin

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Cerulenin

Product Documents for Cerulenin

COA

Certificate of Analysis

SDS

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