CDP 840 hydrochloride

Name: CDP 840 hydrochloride
Brand: Tocris Bioscience
SKU: 3936

Tocris Bioscience, part of Bio-Techne | Catalog # 3936

COA / SDS

Potent and selective PDE4 inhibitor

Discontinued Product

3936 has been discontinued. View all Phosphodiesterase Inhibitors products.

Key Product Details

Description:	Potent and selective PDE4 inhibitor
Chemical Name:	4-[(2R)-2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-pyridine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	409.95

View Full Technical Details for CDP 840 hydrochloride

Technical Data
Citations

Biological Activity for CDP 840 hydrochloride

CDP 840 hydrochloride is a potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC₅₀ = 12 nM for native PDE4). Competitively inhibits all PDE4 isoenzymes (IC₅₀ values are 4, 9, 9 and 45 nM for PDE4A, PDE4B, PDE4C and PDE4D human recombinant isoforms expressed in yeast).

Technical Data for CDP 840 hydrochloride

M. Wt	409.95
Formula	C₂₅H₂₇NO₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
PubChem ID	89809670
InChi Key	DQXFOLCDYKWSIT-GNAFDRTKSA-N
Smiles	COC1=C(OC2CCCC2)C=C([C@@H]([C@]4=CC=CC=C4)CC3=CC=NC=C3)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for CDP 840 hydrochloride

References are publications that support the biological activity of the product.

Perry CDP840: a novel inhibitor of PDE-4. Cell Biochem.Biophys. 1998 PMID: 9631241
Cooper A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo. Br.J.Pharmacol. 1999 PMID: 10372831
Hughes The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. Br.J.Pharmacol. 1996 PMID: 8818342

CDP 840 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3936

Key Product Details

Biological Activity for CDP 840 hydrochloride

Technical Data for CDP 840 hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for CDP 840 hydrochloride

Product Documents for CDP 840 hydrochloride

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected