CDK8/19i

Tocris Bioscience, part of Bio-Techne | Catalog # 7372

Potent and selective CDK8 and CDK19 inhibitor; maintains pluripotency of mouse PSCs in culture
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Key Product Details

Description

Potent and selective CDK8 and CDK19 inhibitor; maintains pluripotency of mouse PSCs in culture

View all Transcriptional Cyclin-dependent Kinase Inhibitors »

Product Description

CDK8/19i is a potent and selective CDK8 and CDK19 inhibitor (IC50 values are 2.9 and 14.1 nM, respectively). CDK8/19i maintains pluripotency of mouse PSCs in culture. It induces the formation of dome-shaped colonies and upregulates Nanog-GFP reporter and endogenous Nanog expression in mouse ESCs in vitro.

Product Specifications

Molecular Weight

253.30

Formula

C14H15N5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-Propyl-3-(4-pyridinyl)imidazo[1,2-b]pyridazin-6-amine

CAS Number

923596-52-5

PubChem ID

68488430

InChI Key

XTMROGQLIVGYKF-UHFFFAOYSA-N

SMILES

CCCNC1=NN2C(C=C1)=NC=C2C3=CC=NC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.33 100
Ethanol 25.33 100

Preparing Stock Solutions for CDK8/19i

The following data is based on the product molecular weight 253.30

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.95 mL 19.74 mL 39.48 mL
5 mM 0.79 mL 3.95 mL 7.90 mL
10 mM 0.39 mL 1.97 mL 3.95 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for CDK8/19i

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CDK8/19i

For research use only

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