CD38 inhibitor 78c

Name: CD38 inhibitor 78c
Brand: Tocris Bioscience
SKU: 6391

Tocris Bioscience, part of Bio-Techne | Catalog # 6391

Citations (8)

COA / SDS

Potent CD38 inhibitor; active in vivo

Key Product Details

Description:	Potent CD38 inhibitor; active in vivo
Chemical Name:	4-[[trans-4-(2-Methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-quinolinone
Purity:	≥98% (HPLC)
Molecular Weight:	413.54

View Full Technical Details for CD38 inhibitor 78c

Technical Data
Citations

Biological Activity for CD38 inhibitor 78c

CD38 inhibitor 78c is a potent CD38 (ADP ribosyl cyclase/hydrolase) inhibitor (IC₅₀ values are 1.9 and 7.3 nM at mouse and human CD38, respectively). Catalyzes breakdown of NAD to nicotinamide and ADPR, and hydrolyzes NAADP to adenosine-5'-O-diphosphoribose phosphate. Elevates NAD⁺ levels >5-fold in liver and >1.2-fold in muscle of diet-induced obese (DIO) C57Bl6 mice. Also prevents age-related NAD⁺ decline in mice. Improves glucose intolerance, cardiac function and improves physiological and metabolic parameters in old mice.

Technical Data for CD38 inhibitor 78c

M. Wt	413.54
Formula	C₂₂H₂₇N₃O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1700637-55-3
PubChem ID	118736856
InChi Key	VJQALSOBHVEJQM-QAQDUYKDSA-N
Smiles	COCCO[C@H]1CC[C@H](NC2=CC(N(C3=CC=C(C4=CN=CS4)C=C23)C)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CD38 inhibitor 78c

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.35	100

Preparing Stock Solutions for CD38 inhibitor 78c

The following data is based on the product molecular weight 413.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.42 mL	12.09 mL	24.18 mL
5 mM	0.48 mL	2.42 mL	4.84 mL
10 mM	0.24 mL	1.21 mL	2.42 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for CD38 inhibitor 78c

References are publications that support the biological activity of the product.

Haffner Discovery, synthesis, and biological evaluation of thiazoloquin(az)olin(on)es as potent CD38 inhibitors. J.Med.Chem. 2015 PMID: 25828863
Tarrago A potent and specific CD38 inhibitor ameliorates age-related metabolic dysfunction by reversing tissue NAD⁺ decline. Cell Metab. 2018 PMID: 29719225