CD 2314
Tocris Bioscience, part of Bio-Techne | Catalog # 3824
Selective RARβ agonist
Product Description
CD 2314 is a potent and selective RARβ receptor agonist (Kd values are 145 and >3760 nM for RARβ and RARα receptors respectively; no binding detected at RARγ). Inhibits growth of human HNSCC 22B, 183A and 22A cells (IC50 values are 3.0, 5.7 and 8.0 μM respectively).Product Specifications
Molecular Weight
364.50
Formula
C23H24O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
5-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)-3-thiophenecarboxylic acid
CAS Number
170355-37-0
PubChem ID
15293210
InChI Key
URUSABQSUCBGGJ-UHFFFAOYSA-N
SMILES
CC(CCC(C)4C)(C)C1=C4C=C(C=CC(C3=CC(C(O)=O)=CS3)=C2)C2=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.45 | 100 |
Preparing Stock Solutions
for CD 2314
The following data is based on the product molecular weight 364.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.74 mL | 13.72 mL | 27.43 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.49 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Szondy Inhibition of activation-induced apoptosis of thymocytes by all-trans- and 9-cis-retinoic acid is mediated via retinoic acid receptor alpha. Biochem.J. 1998 PMID: 9560303
- Zhao Mechanism of regulation and suppression of melanoma invasiveness by novel retinoic acid receptor-gamma target gene carbohydrate sulfotransferase 10. Cancer Res. 2009 PMID: 19470764
- Sun Identification of receptor-selective retinoids that are potent inhibitors of the growth of human head and neck squamous cell carcinoma cells. Clin.Cancer Res. 2000 PMID: 10778990
Product Specific Notices for CD 2314
For research use only
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