CCCP
Tocris Bioscience, part of Bio-Techne | Catalog # 0452
Oxidative phosphorylation uncoupler
Key Product Details
Description
Oxidative phosphorylation uncoupler
Product Description
CCCP is a protonophore. It disrupts mitochondria membrane potential by transporting protons across the mitochondrial inner membrane, which interferes with the proton gradient and ATP synthesis. CCCP is a widely used as an uncoupler of oxidative phosphorylation to induce mitochondrial depolarization.Product Specifications
Molecular Weight
204.62
Formula
C9H5ClN4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
Carbonyl cyanide 3-chlorophenylhydrazone
CAS Number
555-60-2
PubChem ID
2603
InChI Key
UGTJLJZQQFGTJD-UHFFFAOYSA-N
SMILES
ClC1=CC=CC(N/N=C(C#N)\C#N)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.46 | 100 |
Preparing Stock Solutions
for CCCP
The following data is based on the product molecular weight 204.62
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.89 mL | 24.44 mL | 48.87 mL |
| 5 mM | 0.98 mL | 4.89 mL | 9.77 mL |
| 10 mM | 0.49 mL | 2.44 mL | 4.89 mL |
| 50 mM | 0.10 mL | 0.49 mL | 0.98 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Heytler and Pritchard A new class of uncoupling agents - carbonyl cyanide phenylhydrazones. Biochem.Biophys.Res.Commun. 1962 PMID: 13907155
Product Specific Notices for CCCP
For research use only
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