CBR-470-1

Tocris Bioscience, part of Bio-Techne | Catalog # 7018

PGK1 inhibitor; activates Nrf2
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Key Product Details

Description

PGK1 inhibitor; activates Nrf2

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Product Description

CBR-470-1 is a phosphoglycerate kinase 1 (PGK1) inhibitor. CBR-470-1 promotes accumulation of the reactive metabolites methylglyoxal (MGO) resulting in KEAP1 modification and dimerization, which in turn leads to activation of the Nrf2 transcriptional program. CBR-470-1 protects SH-SY5Y neuroblastoma cells from MPP+-induced cytotoxicity via the Keap1-Nrf2 cascade.

Product Specifications

Molecular Weight

365.89

Formula

C14H20ClNO4S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(3R,4S)-rel-4-[(4-Chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-3-thiophenamine-1,1-dioxide

CAS Number

2416095-06-0

PubChem ID

20898025

InChI Key

NFEQFEDSWINARK-KBPBESRZSA-N

SMILES

CC(CN[C@H]1CS(=O)(C[C@@H]1S(=O)(C2=CC=C(C=C2)Cl)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.59 100
Ethanol 7.32 20

Preparing Stock Solutions for CBR-470-1

The following data is based on the product molecular weight 365.89

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.67 mL 27.33 mL
5 mM 0.55 mL 2.73 mL 5.47 mL
10 mM 0.27 mL 1.37 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for CBR-470-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CBR-470-1

For research use only

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