CBMR 0083
Tocris Bioscience, part of Bio-Techne | Catalog # 7890
Potent allosteric FFA1 (GPR40) and 4 (GPR120) agonist
Key Product Details
Description
Potent allosteric FFA1 (GPR40) and 4 (GPR120) agonist
Product Description
CBMR 0083 is a potent allosteric free fatty acid receptor 1 (FFA1) and 4 (FFA4) agonist (EC50 values are 1 and 2 nM for FFA1 and FFA4, respectively).Product Specifications
Molecular Weight
487.39
Formula
C23H24Cl2N6O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-[3-[[4-Amino-6-[[2-(2,5-dichlorophenyl)ethyl]amino]-1,3,5-triazin-2-yl]methoxy]-5-methylphenyl]-2-pyrrolidinone
CAS Number
2839486-16-5
PubChem ID
167312323
InChI Key
AIIZGUNRDJPXHF-UHFFFAOYSA-N
SMILES
O=C1N(CCC1)C2=CC(OCC3=NC(NCCC4=CC(Cl)=CC=C4Cl)=NC(N)=N3)=CC(C)=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.74 | 100 |
Preparing Stock Solutions
for CBMR 0083
The following data is based on the product molecular weight 487.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.05 mL | 10.26 mL | 20.52 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.10 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.05 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lückmann Optimization of first-in-class dual-acting FFAR1/FFAR4 allosteric modulators with novel mode of action. ACS Med.Chem.Lett. 2022 PMID: 36518697
Product Specific Notices for CBMR 0083
For research use only
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