CATPB
Tocris Bioscience, part of Bio-Techne | Catalog # 5903
FFA2 (GPR43) inverse agonist
Key Product Details
Description
FFA2 (GPR43) inverse agonist
Product Description
CATPB is a FFA2 inverse agonist (pKi = 7.87). Selective for human over mouse FFA2. Increases forskolin-induced cAMP production and inhibits acetate-induced MAPK signaling in cells expressing human FFA2.Product Specifications
Molecular Weight
399.79
Formula
C19H17ClF3NO3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid
CAS Number
1322598-09-3
PubChem ID
53308747
InChI Key
QOSIJVVNNGXEKE-INIZCTEOSA-N
SMILES
OC(C[C@@H](NC(CC1=CC=CC(Cl)=C1)=O)CC2=CC=C(C(F)(F)F)C=C2)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.98 | 100 | |
| Ethanol | 19.99 | 50 |
Preparing Stock Solutions
for CATPB
The following data is based on the product molecular weight 399.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.50 mL | 12.51 mL | 25.01 mL |
| 5 mM | 0.50 mL | 2.50 mL | 5.00 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.50 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sergeev Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands. J.Biol.Chem. 2016 PMID: 26518871
- Park Selective novel inverse agonists for human GPR43 augment GLP-1 secretion. Eur.J.Pharmacol. 2016 PMID: 26683635
Product Specific Notices for CATPB
For research use only
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