Capzimin dimer
Tocris Bioscience, part of Bio-Techne | Catalog # 6781
Selective proteasome inhibitor
Product Description
Capzimin dimer is a specific inhibitor of proteasome isopeptidase Rpn11 (IC50 = 2.1 μM and 3.8 μM, in 293T and A549 cell lines, respectively). It exhibits 80-fold selectivity for Rpn11 over Csn5, ten-fold over AMSH and six-fold over BRCC36 (IC50 = 30 μM, 4.5 μM, and 2.3 μM, respectively). Capzimin dimer blocks proliferation of cancer cells.Product Specifications
Molecular Weight
628.80
Formula
C30H24N6O2S4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
8,8'-Dithiobis[N-[2-(2-thiazolyl)ethyl]-3-quinolinecarboxamide]
CAS Number
2084868-04-0
PubChem ID
126599606
InChI Key
RNEOHKZPZKEZCQ-UHFFFAOYSA-N
SMILES
O=C(C1=CC2=C(C(SSC3=CC=CC4=C3N=CC(C(NCCC5=NC=CS5)=O)=C4)=CC=C2)N=C1)NCCC6=NC=CS6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 62.88 | 100 |
Preparing Stock Solutions
for Capzimin dimer
The following data is based on the product molecular weight 628.80
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.59 mL | 7.95 mL | 15.90 mL |
| 5 mM | 0.32 mL | 1.59 mL | 3.18 mL |
| 10 mM | 0.16 mL | 0.80 mL | 1.59 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.32 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Li Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat.Chem.Biol. 2017 PMID: 28244987
- Perez Discovery of an inhibitor of the proteasome subunit Rpn11. J.Med.Chem. 2017 PMID: 28191850
Product Specific Notices for Capzimin dimer
For research use only
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