Camptothecin
Tocris Bioscience, part of Bio-Techne | Catalog # 1100
DNA topoisomerase inhibitor
Product Description
Camptothecin is a cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. Induces single strand DNA breaks and protein-DNA crosslinks.Product Specifications
Molecular Weight
348.36
Formula
C20H16N2O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(S)-4-Ethyl-4-hydroxy-1H-pyrano-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS Number
7689-03-4
PubChem ID
24360
InChI Key
VSJKWCGYPAHWDS-FQEVSTJZSA-N
SMILES
O=C4C5=C([C@](CC)(O)C(OC5)=O)C=C3C2=NC1=CC=CC=C1C=C2CN34
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5 |
Preparing Stock Solutions
for Camptothecin
The following data is based on the product molecular weight 348.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 57.41 mL | 287.06 mL | 574.12 mL |
| 0.25 mM | 11.48 mL | 57.41 mL | 114.82 mL |
| 0.5 mM | 5.74 mL | 28.71 mL | 57.41 mL |
| 2.5 mM | 1.15 mL | 5.74 mL | 11.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hsiang Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J.Biol.Chem. 1985 PMID: 2997227
- Pantazis Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro. Int.J.Cancer 1993 PMID: 8449612
- Liu DNA topoisomerase poisons as antitumour drugs. Annu.Rev.Biochem 1989 PMID: 2549853
Product Specific Notices for Camptothecin
For research use only
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