CaCCinh-A01
Tocris Bioscience, part of Bio-Techne | Catalog # 4877
Calcium-activated chloride channel (CaCC) inhibitor
Key Product Details
Description
Calcium-activated chloride channel (CaCC) inhibitor
Product Description
CaCCinh-A01 is a calcium-activated chloride channel (CaCC) inhibitor (IC50 ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50 = 2.1 μM, in TMEM16A-expressing FRT cells).Product Specifications
Molecular Weight
347.43
Formula
C18H21NO4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
CAS Number
407587-33-1
PubChem ID
2898877
InChI Key
ACLUEOBQFRYTQS-UHFFFAOYSA-N
SMILES
CC(C)(C)C1CCC2=C(SC(NC(C3=CC=CO3)=O)=C2C(O)=O)C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.74 | 100 | |
| Ethanol | 3.47 | 10 with gentle warming |
Preparing Stock Solutions
for CaCCinh-A01
The following data is based on the product molecular weight 347.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.88 mL | 14.39 mL | 28.78 mL |
| 5 mM | 0.58 mL | 2.88 mL | 5.76 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.88 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- De La Fuente Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol.Pharmacol. 2008 PMID: 18083779
- Namkung TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J.Biol.Chem. 2011 PMID: 21084298
Product Specific Notices for CaCCinh-A01
For research use only
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