Cabergoline

Name: Cabergoline
Brand: Tocris Bioscience
SKU: 2664

Tocris Bioscience, part of Bio-Techne | Catalog # 2664

Citations (24)

COA / SDS

D2-like agonist (D2>D3>D4)

Key Product Details

Description:	D₂-like agonist (D₂>D₃>D₄)
Chemical Name:	N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8-carboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	451.6

View Full Technical Details for Cabergoline

Technical Data
Citations

Biological Activity for Cabergoline

Cabergoline is a selective D₂-like dopamine receptor agonist (K_i values are 0.7, 1.5, 9.0 and 165 nM for D₂, D₃, D₄ and D₅ receptors respectively) that also displays high affinity for several serotonin receptor subtypes (K_i = 1.2 - 20.0 nM for 5-HT_1A, 5-HT_1D, 5-HT_2A and 5-HT_2B). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.

Compound Libraries for Cabergoline

Cabergoline is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Cabergoline

M. Wt	451.6
Formula	C₂₆H₃₇N₅O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	81409-90-7
PubChem ID	90488776
InChi Key	MNDMRWBGBXWMDE-YPAWHYETSA-N
Smiles	C=CCN1[C@]([C@]2([H])C[C@@H](C(N(C(NCC)=O)CCCN(C)C)=O)C1)([H])CC3=CNC4=CC=CC2=C43

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cabergoline

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.16	100
	ethanol	45.16	100

Preparing Stock Solutions for Cabergoline

The following data is based on the product molecular weight 451.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.07 mL	22.14 mL
5 mM	0.44 mL	2.21 mL	4.43 mL
10 mM	0.22 mL	1.11 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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Reconstitution Calculator

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References for Cabergoline

References are publications that support the biological activity of the product.

Kvernmo A review of the receptor-binding and pharmacokinetic properties of DA agonists. Clin.Ther. 2006 PMID: 16982285
Hadj Tahar Sustained caberg. treatment reverses levodopa-induced dyskinesias in parkinsonian monkeys. Cin.Neuropharmacol.
Eguchi Effect of cabergoline, a DA agonist, on estrogen-induced rat pituitary tumors:in vitro culture studies. Endocr.J. 1995 PMID: 7670571