Cabergoline
Tocris Bioscience, part of Bio-Techne | Catalog # 2664
D2-like agonist (D2>D3>D4)
Key Product Details
Description
D2-like agonist (D2>D3>D4)
Product Description
Cabergoline is a selective D2-like dopamine receptor agonist (Ki values are 0.7, 1.5, 9.0 and 165 nM for D2, D3, D4 and D5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (Ki = 1.2 - 20.0 nM for 5-HT1A, 5-HT1D, 5-HT2A and 5-HT2B). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.Product Specifications
Molecular Weight
451.60
Formula
C26H37N5O2
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8-carboxamide
CAS Number
81409-90-7
PubChem ID
90488776
InChI Key
MNDMRWBGBXWMDE-YPAWHYETSA-N
SMILES
C=CCN1[C@]([C@]2([H])C[C@@H](C(N(C(NCC)=O)CCCN(C)C)=O)C1)([H])CC3=CNC4=CC=CC2=C43
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.16 | 100 | |
| Ethanol | 45.16 | 100 |
Preparing Stock Solutions
for Cabergoline
The following data is based on the product molecular weight 451.60
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.07 mL | 22.14 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.43 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kvernmo A review of the receptor-binding and pharmacokinetic properties of DA agonists. Clin.Ther. 2006 PMID: 16982285
- Hadj Tahar Sustained caberg. treatment reverses levodopa-induced dyskinesias in parkinsonian monkeys. Cin.Neuropharmacol.
- Eguchi Effect of cabergoline, a DA agonist, on estrogen-induced rat pituitary tumors:in vitro culture studies. Endocr.J. 1995 PMID: 7670571
Product Specific Notices for Cabergoline
For research use only
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