Product Description
C16 is a PKR inhibitor (IC50 = 210 nM). Rescues PKR-dependent translation block in vitro. Decreases Aβ42-induced inflammatory cytokine release and apoptosis in neuronal cultures. Prevents neuroinflammation and neuronal loss in an acute excitotoxic rat model. Brain penetrant.Product Specifications
Molecular Weight
268.29
Formula
C13H8N4OS
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
CAS Number
608512-97-6
PubChem ID
6490494
InChI Key
VFBGXTUGODTSPK-BAQGIRSFSA-N
SMILES
O=C2NC1=CC=C4C(SC=N4)=C1/C2=C/C3=CNC=N3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.41 | 50 | |
| Ethanol | 5.37 | 20 |
Preparing Stock Solutions
for C16
The following data is based on the product molecular weight 268.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 7.45 mL | 37.27 mL | 74.55 mL |
| 2.5 mM | 1.49 mL | 7.45 mL | 14.91 mL |
| 5 mM | 0.75 mL | 3.73 mL | 7.45 mL |
| 25 mM | 0.15 mL | 0.75 mL | 1.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Tronel The specific PKR inhibitor C16 prevents apoptosis and IL-1 beta production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem.Int. 2014 PMID: 24211709
- Ingrand The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. FEBS Lett. 2007 PMID: 17761171
- Couturier Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures. J.Neuroinflammation 2011 PMID: 21699726
- Jammi Small molecule inhibitors of the RNA-dependent protein kinase. Biochem.Biophys.Res.Comm. 2003 PMID: 12890478
Product Specific Notices for C16
For research use only
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